Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402417 | 0.94 | CHRM4 (0.49) | CHRM4GAASMN1; SMN2PPARAALDH1A1 | |
| SCHEMBL3403817 | 0.94 | CHRM4 (0.49) | CHRM4GAASMN1; SMN2PPARAALDH1A1 | |
| SCHEMBL3402600 | 0.92 | CHRM4 (0.49) | CHRM4GAASMN1; SMN2SCN9AEPHX2 | |
| SCHEMBL3399568 | 0.91 | CHRM4 (0.51) | CHRM4GAASMN1; SMN2SCN9APPARA | |
| SCHEMBL3400096 | 0.91 | CHRM4 (0.49) | CHRM4GAASMN1; SMN2SCN9AEPHX2 | |
| SCHEMBL3400929 | 0.90 | SCN9A (0.49) | CHRM4GAASMN1; SMN2SCN9ATSHR | |
| SCHEMBL3406027 | 0.90 | CHRM4 (0.50) | CHRM4GAASMN1; SMN2SCN9APPARA | |
| SCHEMBL3402105 | 0.87 | CHRM4 (0.47) | CHRM4GAASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3401053 | 0.86 | CHRM4 (0.47) | CHRM4GAASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3405210 | 0.86 | CHRM4 (0.51) | CHRM4GAASMN1; SMN2PPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |