Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405545 | 0.99 | CHRM4 (0.50) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL3400864 | 0.94 | GAA (0.50) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL3400078 | 0.93 | CHRM4 (0.49) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL14545337 | 0.91 | CHRM4 (0.48) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL3396893 | 0.87 | SCN9A (0.48) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL3399568 | 0.86 | CHRM4 (0.51) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL3399475 | 0.86 | CHRM4 (0.51) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL3406027 | 0.85 | CHRM4 (0.50) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL3401256 | 0.85 | GAA (0.47) | CHRM4GAANPSR1NPC1HPGD | |
| SCHEMBL3400096 | 0.84 | CHRM4 (0.49) | CHRM4GAAALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |