Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | GPR4 | P46093 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | TACR2 | P21452 | 2/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400874 | 0.96 | HRH3 (0.36) | KDM4EALDH1A1TDP1BCHEACHE | |
| SCHEMBL13072167 | 0.89 | KMT2A (0.39) | KDM4EGNRHR | |
| SCHEMBL3404520 | 0.81 | TACR2 (0.43) | KDM4EHRH3KCNH2TACR2TACR3 | |
| SCHEMBL3400819 | 0.78 | HTR2C (0.46) | KDM4EALDH1A1MAOB | |
| SCHEMBL3405240 | 0.75 | HTR2C (0.45) | KDM4EALDH1A1TACR2 | |
| SCHEMBL5929244 | 0.73 | RXFP1 (0.40) | KDM4EALDH1A1KCNH2 | |
| SCHEMBL12030410 | 0.67 | TACR2 (0.46) | KDM4EALDH1A1HRH3KCNH2TACR2 | |
| SCHEMBL18705076 | 0.67 | CXCR4 (0.46) | KDM4EALDH1A1TDP1BCHEACHE | |
| SCHEMBL5928960 | 0.67 | GABRA1 (0.42) | KDM4EALDH1A1KCNH2 | |
| Hydrochloric Acid SCHEMBL2484779 | 0.67 | TACR2 (0.45) | KDM4EALDH1A1HRH3KCNH2TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |