Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309670 | 1.00 | HRH3 (0.51) | HRH3CYP2D6CYP2C19NPSR1HTR2C | |
| SCHEMBL3401081 | 0.92 | LMNA (0.47) | HRH3NPSR1HTR2CCNR1THRA | |
| SCHEMBL13071970 | 0.91 | HRH3 (0.58) | HRH3CYP2D6CYP2C19NPSR1HTR2C | |
| SCHEMBL3404999 | 0.91 | HRH3 (0.58) | HRH3CYP2D6CYP2C19NPSR1HTR2C | |
| SCHEMBL3403457 | 0.89 | HRH3 (0.54) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL13071649 | 0.89 | HRH3 (0.54) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3401804 | 0.88 | HRH3 (0.51) | HRH3CYP2D6CYP2C19NPSR1HTR2C | |
| SCHEMBL3405822 | 0.88 | HRH3 (0.51) | HRH3CYP2D6CYP2C19NPSR1HTR2C | |
| SCHEMBL3404798 | 0.87 | HRH3 (0.50) | HRH3CYP2D6CYP2C19NPSR1HTR2C | |
| SCHEMBL13309673 | 0.87 | HRH3 (0.50) | HRH3CYP2D6CYP2C19NPSR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |