Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.87 |
| ▸ | DRD3 | P35462 | 14/20 | 0.87 |
| ▸ | DRD4 | P21917 | 5/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399254 | 0.93 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL8452211 | 0.84 | DRD2 (0.69) | DRD2DRD3DRD4ADRB1DRD5 | |
| SCHEMBL2131518 | 0.82 | DRD2 (0.67) | DRD2DRD3DRD4ADRB1DRD5 | |
| SCHEMBL30751119 | 0.82 | DRD2 (0.67) | DRD2DRD3DRD4ADRB1DRD5 | |
| SCHEMBL3395428 | 0.81 | DRD2 (0.62) | DRD2DRD3DRD4HTR1AADRB1 | |
| SCHEMBL21599144 | 0.81 | DRD2 (0.56) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL24399496 | 0.80 | KDM4E (0.75) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL22302770 | 0.80 | DRD2 (0.89) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL424507 | 0.80 | DRD2 (0.75) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL12359055 | 0.77 | DRD2 (0.71) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003418-A2 | FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-05 | — | — | WO | disclosed |