Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | PAICS | P22234 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314825 | 0.91 | CXCR4 (0.45) | HRH3CXCR4PAICSKDM5CKDM4C | |
| SCHEMBL465732 | 0.91 | HRH3 (0.53) | HRH3CXCR4SMN1; SMN2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL2770716 | 0.90 | HRH3 (0.52) | HRH3CXCR4SMN1; SMN2KDM4EMAPT | |
| SCHEMBL17403600 | 0.86 | HRH3 (0.55) | HRH3CXCR4SMN1; SMN2KDM4EMAPT | |
| SCHEMBL3399676 | 0.82 | HIF1A (0.47) | HRH3CXCR4SMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL530048 | 0.77 | HRH3 (0.53) | HRH3KCNH2 | |
| SCHEMBL15972046 | 0.77 | HRH3 (0.47) | HRH3CXCR4SMN1; SMN2KDM4EMAPT | |
| SCHEMBL17403599 | 0.75 | SCN9A (0.41) | SMN1; SMN2KDM4EKDM5CKDM4C | |
| SCHEMBL1126270 | 0.73 | GAA (0.49) | HRH3SMN1; SMN2KDM4EMAPTNPC1 | |
| SCHEMBL13187501 | 0.73 | HRH3 (0.53) | HRH3CXCR4SMN1; SMN2KDM4EHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |