Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.44 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PAICS | P22234 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399672 | 0.82 | HRH3 (0.47) | HIF1AEPAS1HRH3CXCR4KDM5C | |
| SCHEMBL25798032 | 0.80 | HIF1A (0.51) | HIF1AEPAS1HRH3CXCR4PDE7A | |
| SCHEMBL17240067 | 0.76 | HIF1A (0.58) | HIF1AEPAS1HRH3CXCR4PDE7A | |
| SCHEMBL13452765 | 0.72 | HRH3 (0.53) | HIF1AEPAS1HRH3CXCR4ALOX15 | |
| SCHEMBL20160684 | 0.72 | CXCR4 (0.49) | HRH3CXCR4KDM5CKDM4CKCNH2 | |
| SCHEMBL3314825 | 0.72 | CXCR4 (0.45) | HRH3CXCR4MAPK7KDM5CKDM4C | |
| SCHEMBL13187501 | 0.72 | HRH3 (0.53) | HIF1AEPAS1HRH3CXCR4ALOX15 | |
| SCHEMBL3065752 | 0.72 | CXCR4 (0.45) | HRH3CXCR4KDM5CKDM4C | |
| SCHEMBL13764446 | 0.72 | CXCR4 (0.45) | HRH3CXCR4MAPK7KDM5CKDM4C | |
| SCHEMBL110617 | 0.72 | HRH3 (0.53) | HIF1AEPAS1HRH3CXCR4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |