Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.55 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | POLR1A | O95602 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399888 | 0.84 | CHRM4 (0.45) | CHRM4 | |
| SCHEMBL3402294 | 0.84 | CHRM4 (0.56) | CHRM4ACKR3LCKEEDPPARA | |
| SCHEMBL3401302 | 0.84 | CHRM4 (0.53) | CHRM4ACKR3PPARACHRM3 | |
| SCHEMBL3404888 | 0.84 | CHRM4 (0.53) | CHRM4ACKR3PPARACHRM3 | |
| SCHEMBL3405722 | 0.84 | CHRM4 (0.50) | CHRM4ACKR3LCKPPARABTK | |
| SCHEMBL3404959 | 0.84 | CHRM4 (0.44) | CHRM4 | |
| SCHEMBL13309884 | 0.83 | CHRM4 (0.51) | CHRM4ACKR3PPARACHRM3 | |
| SCHEMBL3399661 | 0.82 | CHRM4 (0.53) | CHRM4ACKR3LCKPPARACHRM3 | |
| SCHEMBL3405415 | 0.82 | CHRM4 (0.54) | CHRM4ACKR3LCKPPARAPOLR1A | |
| SCHEMBL3401074 | 0.81 | THRB (0.47) | CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |