Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.57 |
| ▸ | PPARD | Q03181 | 5/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.54 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401785 | 0.91 | ACKR3 (0.54) | PPARAPPARDCHRM4ACKR3PPARG | |
| SCHEMBL3398440 | 0.91 | ACKR3 (0.51) | PPARAPPARDCHRM4ACKR3CHRM3 | |
| SCHEMBL3403598 | 0.90 | ACKR3 (0.53) | PPARAPPARDCHRM4ACKR3PPARG | |
| SCHEMBL3405442 | 0.89 | ACKR3 (0.59) | PPARAPPARDCHRM4ACKR3NPC1 | |
| SCHEMBL3405198 | 0.89 | CHRM4 (0.67) | PPARAPPARDCHRM4ACKR3PPARG | |
| SCHEMBL3405220 | 0.88 | ACKR3 (0.52) | PPARAPPARDCHRM4ACKR3NPC1 | |
| SCHEMBL3405398 | 0.88 | ACKR3 (0.55) | PPARAPPARDCHRM4ACKR3PPARG | |
| SCHEMBL13310379 | 0.87 | ACKR3 (0.50) | PPARAPPARDCHRM4ACKR3PPARG | |
| SCHEMBL3403946 | 0.86 | CHRM4 (0.56) | PPARAPPARDCHRM4ACKR3PPARG | |
| SCHEMBL3402589 | 0.86 | ACKR3 (0.51) | PPARAPPARDCHRM4ACKR3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |