Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 8/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.52 |
| ▸ | PPARD | Q03181 | 4/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401785 | 0.99 | ACKR3 (0.54) | ACKR3PPARACHRM4PPARDACP1 | |
| SCHEMBL3403412 | 0.92 | CHRM4 (0.49) | ACKR3PPARACHRM4PPARDACP1 | |
| SCHEMBL3405442 | 0.92 | ACKR3 (0.59) | ACKR3PPARACHRM4PPARDACP1 | |
| SCHEMBL3405220 | 0.91 | ACKR3 (0.52) | ACKR3PPARACHRM4PPARDMAPT | |
| SCHEMBL3399982 | 0.90 | PPARA (0.57) | ACKR3PPARACHRM4PPARDCHRM3 | |
| SCHEMBL13310379 | 0.89 | ACKR3 (0.50) | ACKR3PPARACHRM4PPARDMAPT | |
| SCHEMBL3400075 | 0.89 | ACKR3 (0.54) | ACKR3PPARACHRM4PPARDACP1 | |
| SCHEMBL3405398 | 0.89 | ACKR3 (0.55) | ACKR3PPARACHRM4PPARDMAPT | |
| SCHEMBL3402603 | 0.88 | TLR9 (0.53) | ACKR3PPARACHRM4PPARDMAPT | |
| SCHEMBL3399830 | 0.88 | ACKR3 (0.54) | ACKR3PPARACHRM4PPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |