Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.54 |
| ▸ | PPARD | Q03181 | 6/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402266 | 0.86 | PPARA (0.49) | PPARAPPARDPPARGCNR1SMN1; SMN2 | |
| SCHEMBL3404075 | 0.86 | PPARA (0.58) | PPARAPPARDPPARGCNR1SMN1; SMN2 | |
| SCHEMBL13071969 | 0.85 | CHRM4 (0.54) | PPARAPPARDPPARGCNR1SMN1; SMN2 | |
| SCHEMBL3399546 | 0.85 | PPARA (0.48) | PPARAPPARDPPARGCNR1SMN1; SMN2 | |
| SCHEMBL3402398 | 0.85 | NPC1 (0.62) | PPARAPPARDPPARGHDAC4HDAC6 | |
| SCHEMBL3401401 | 0.83 | PPARA (0.53) | PPARAPPARDPPARGCNR1SMN1; SMN2 | |
| SCHEMBL3403484 | 0.83 | PPARA (0.49) | PPARAPPARDPPARGCNR1ALDH1A1 | |
| SCHEMBL3404893 | 0.83 | PPARA (0.50) | PPARAPPARDPPARGCNR1SMN1; SMN2 | |
| SCHEMBL3399603 | 0.83 | PPARA (0.55) | PPARAPPARDPPARGCNR1HDAC4 | |
| SCHEMBL3405227 | 0.82 | PPARA (0.48) | PPARAPPARDPPARGCNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |