Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.53 |
| ▸ | PPARD | Q03181 | 5/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404075 | 0.89 | PPARA (0.58) | PPARAPPARDCNR1ALDH1A1NPSR1 | |
| SCHEMBL13071969 | 0.88 | CHRM4 (0.54) | PPARAPPARDCNR1ALDH1A1NPSR1 | |
| SCHEMBL3403484 | 0.86 | PPARA (0.49) | PPARAPPARDCNR1ALDH1A1PPARG | |
| SCHEMBL3404893 | 0.86 | PPARA (0.50) | PPARAPPARDCNR1ALDH1A1NPSR1 | |
| SCHEMBL3399603 | 0.85 | PPARA (0.55) | PPARAPPARDCNR1ALDH1A1CHRM4 | |
| SCHEMBL3405227 | 0.84 | PPARA (0.48) | PPARAPPARDCNR1HPGDCHRM4 | |
| SCHEMBL3400415 | 0.84 | PPARA (0.53) | PPARAPPARDCNR1PPARGNPC1 | |
| SCHEMBL3400002 | 0.83 | PPARA (0.54) | PPARAPPARDCNR1ALDH1A1NPSR1 | |
| SCHEMBL3402266 | 0.82 | PPARA (0.49) | PPARAPPARDCNR1ALDH1A1NPSR1 | |
| SCHEMBL3399546 | 0.82 | PPARA (0.48) | PPARAPPARDCNR1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |