Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1347807 | 0.86 | AVPR1A (0.39) | BRD4 | |
| SCHEMBL3403602 | 0.85 | TNKS2 (0.35) | BRD4TGFBR1MAPK14THRBTNKS | |
| SCHEMBL3399961 | 0.83 | TNKS2 (0.39) | BRD4APLNRTNKSTNKS2P2RX7 | |
| SCHEMBL1347857 | 0.79 | TUBB4A (0.37) | TGFBR1MAPK14THRBAPLNRTUBB4A | |
| SCHEMBL314194 | 0.78 | BRD4 (0.44) | BRD4TGFBR1MAPK14THRBAPLNR | |
| SCHEMBL314707 | 0.76 | PTPN1 (0.38) | TGFBR1MAPK14THRBAPLNRTUBB4A | |
| SCHEMBL314997 | 0.72 | TNKS2 (0.37) | TGFBR1MAPK14THRBAPLNRMAPK1 | |
| SCHEMBL314998 | 0.72 | TNKS2 (0.37) | TGFBR1MAPK14THRBAPLNRMAPK1 | |
| SCHEMBL12131735 | 0.72 | TUBB4A (0.37) | TGFBR1MAPK14THRBTUBB4ATUBB | |
| SCHEMBL314996 | 0.72 | TNKS2 (0.37) | TGFBR1MAPK14THRBAPLNRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111403-B1 | TRIAZABENZO[E]AZULENE DERIVATIVES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2010-11-10 | — | — | EP | claimed |
| EP-2111403-B1 | TRIAZABENZO[E]AZULENE DERIVATIVES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2010-11-10 | — | — | EP | disclosed |