Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206204 | 0.87 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AHTTENPP2 | |
| SCHEMBL205824 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTTENPP2 | |
| SCHEMBL28268704 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AHTTENPP2 | |
| SCHEMBL206309 | 0.78 | HSD17B10 (0.55) | SMN1; SMN2NPC1RAB9AHTTHSD17B10 | |
| SCHEMBL485156 | 0.78 | SMN1; SMN2 (0.75) | SMN1; SMN2NPC1RAB9AHTTENPP2 | |
| SCHEMBL2306241 | 0.77 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AHTTENPP2 | |
| SCHEMBL206214 | 0.77 | KDM4E (0.49) | SMN1; SMN2NPC1RAB9AHTTHSD17B10 | |
| SCHEMBL12699823 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AHTTENPP2 | |
| SCHEMBL3400299 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AHTTENPP2 | |
| SCHEMBL5272899 | 0.77 | KDM4E (0.60) | SMN1; SMN2NPC1RAB9AHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |