Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 5/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114477 | 1.00 | ADRB2 (0.53) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL115948 | 0.89 | ADRB2 (0.50) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL115773 | 0.87 | ADRB2 (0.52) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL114557 | 0.87 | ADRB2 (0.52) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12836926 | 0.84 | ADRB2 (0.49) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL114727 | 0.82 | ADRB2 (0.61) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL145483 | 0.82 | ADRB2 (0.50) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL178577 | 0.82 | ADRB2 (0.50) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL142928 | 0.82 | ADRB2 (0.50) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9283475 | 0.82 | ADRB2 (0.56) | ADRB2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250171-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | Achaogen, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |