Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.34 |
| ▸ | JAK1 | P23458 | 6/20 | 0.34 |
| ▸ | JAK3 | P52333 | 6/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393952 | 0.76 | MAPK1 (0.54) | MAPK1SYK | |
| SCHEMBL3399018 | 0.68 | MAPK1 (0.32) | MAPK1SYK | |
| SCHEMBL25099112 | 0.67 | MAPK1 (0.30) | JAK2JAK1JAK3MAPK1 | |
| SCHEMBL3398135 | 0.66 | SMN1; SMN2 (0.39) | MAPK1SYK | |
| SCHEMBL3396297 | 0.66 | JAK3 (0.44) | JAK3 | |
| SCHEMBL18733454 | 0.66 | JAK3 (0.52) | JAK2JAK1JAK3SYK | |
| SCHEMBL3396270 | 0.65 | CDK8 (0.48) | JAK3MAPK1SYK | |
| SCHEMBL3395308 | 0.64 | MAPK1 (0.34) | JAK3MAPK1SYK | |
| SCHEMBL3397956 | 0.64 | MAPK1 (0.42) | MAPK1 | |
| SCHEMBL18352331 | 0.64 | JAK2 (0.34) | JAK2JAK1JAK3MAPK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247593-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106444-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2247593-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106444-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |