Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398135 | 0.89 | SMN1; SMN2 (0.39) | MAPK1SYK | |
| SCHEMBL651473 | 0.76 | JAK3 (0.42) | SYK | |
| SCHEMBL3396108 | 0.74 | — | — | |
| SCHEMBL3395483 | 0.74 | MAPK1 (0.47) | MAPK1 | |
| SCHEMBL2354699 | 0.71 | MAPK1 (0.40) | MAPK1 | |
| SCHEMBL3400025 | 0.71 | JAK3 (0.32) | — | |
| SCHEMBL3396844 | 0.70 | NOS1 (0.40) | MAPK1SYK | |
| SCHEMBL3398889 | 0.70 | SYK (0.44) | SYK | |
| SCHEMBL3397717 | 0.69 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL3398640 | 0.69 | MAPK1 (0.32) | MAPK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247593-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106444-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2247593-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106444-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |