Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 5/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL203957 | 0.84 | PARP1 (0.57) | PARP1LMNADRD2PARP2 | |
| SCHEMBL206528 | 0.83 | SMN1; SMN2 (0.53) | USP2ALDH1A1TSHRNPSR1LMNA | |
| SCHEMBL207485 | 0.82 | PARP1 (0.50) | PARP1LMNAPARP2 | |
| SCHEMBL205714 | 0.81 | PARP1 (0.49) | DRD4PARP1LMNADRD2PARP2 | |
| SCHEMBL204714 | 0.77 | PARP1 (0.51) | PARP1ALDH1A1PARP2 | |
| SCHEMBL27969428 | 0.77 | BCHE (0.59) | DRD4USP2ALDH1A1TSHRNPSR1 | |
| SCHEMBL206737 | 0.77 | LCK (0.46) | NPSR1 | |
| SCHEMBL5621740 | 0.77 | HTR2B (0.54) | DRD4PARP1ALDH1A1GAAPARP2 | |
| SCHEMBL205895 | 0.76 | SMN1; SMN2 (0.44) | PARP1NPSR1PARP2 | |
| SCHEMBL14157392 | 0.76 | CHRM4 (0.46) | DRD4USP2ALDH1A1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |