Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 20/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.67 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.67 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.67 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.67 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.67 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.67 |
| ▸ | CNR2 | P34972 | 18/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399713 | 0.92 | CNR1 (0.79) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL3396977 | 0.90 | CNR1 (0.72) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL5253139 | 0.90 | CNR1 (0.81) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL3396564 | 0.88 | CNR1 (0.71) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL3399121 | 0.87 | CNR1 (0.72) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL5252425 | 0.86 | CNR1 (0.81) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL3399554 | 0.85 | CNR1 (0.61) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL3394822 | 0.85 | CNR1 (0.72) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL1628949 | 0.85 | CNR1 (0.72) | CNR1GABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL3398162 | 0.83 | CNR1 (0.57) | CNR1GABRA1GABRB1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146997-B1 | SUBSTITUTED FURO[2,3-B]PYRIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2010-11-10 | — | — | EP | disclosed |
| US-20080269279-A1 | Substituted furo[2,3-B] pyridine derivatives as cannabinoid-1 receptor modulators | MERCK SHARP & DOHME CORP. | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269279-A1 | Substituted furo[2,3-B] pyridine derivatives as cannabinoid-1 receptor modulators | CNR1, CNR2, FAAH | CNR1 1/4885GABRA1 66/4885GABRB1 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.