SCHEMBL3400883

SCHEMBL3400883

CC1(c2nc3cccc(C(N)=O)c3o2)CCCN1Cc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 8/20 0.40
ESR1 P03372 1/20 0.39
MAPT P10636 1/20 0.39
MAPK10 P53779 1/20 0.39
KMT2A Q03164 1/20 0.39
HCRTR1 O43613 1/20 0.35
HCRTR2 O43614 1/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP2D6 P10635 1/20 0.35
OPRK1 P41145 2/20 0.35
KCNH2 Q12809 1/20 0.35
OPRM1 P35372 1/20 0.34
PPARG P37231 1/20 0.34
HTR3A P46098 1/20 0.34
DHODH Q02127 1/20 0.34
ADRA1D P25100 1/20 0.34
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3397253 0.85 PARP1 (0.45) PARP1
SCHEMBL204172 0.82 PARP1 (0.41) PARP1ESR1MAPTMAPK10KMT2A
SCHEMBL204570 0.78 PARP1 (0.38) PARP1ESR1MAPTMAPK10KMT2A
SCHEMBL204810 0.74 PARP1 (0.37) PARP1ALDH1A1DHODH
SCHEMBL205393 0.74 HCRTR1 (0.41) ESR1MAPTMAPK10KMT2AHCRTR1
SCHEMBL206585 0.74 DHODH (0.38) PARP1ESR1MAPTMAPK10KMT2A
SCHEMBL206724 0.73 PARP1 (0.36) PARP1ESR1ALDH1A1DHODH
SCHEMBL204539 0.72 ESR1 (0.37) PARP1ESR1ALDH1A1DHODH
SCHEMBL3400558 0.71 DRD4 (0.47) PARP1ALDH1A1OPRK1TSHR
SCHEMBL205900 0.70 PARP1 (0.55) PARP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2247600-A2 BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) Lead Therapeutics, Inc. (US) 2010-11-10 EP disclosed
WO-2009099736-A2 BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) LEAD THERAPEUTICS, INC. (US) 2009-08-13 WO disclosed