Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406737 | 0.83 | TP53 (0.64) | PTGS2TP53ALOX12CA2CA1 | |
| SCHEMBL3402693 | 0.82 | PTGS2 (0.77) | HTTPTGS2TP53ALOX12CA2 | |
| SCHEMBL12530243 | 0.79 | PTGS2 (0.40) | HTTPTGS2 | |
| SCHEMBL20604184 | 0.79 | HTT (0.78) | HTTPTGS2TP53ALOX12CA2 | |
| SCHEMBL32889301 | 0.77 | PTGS2 (0.82) | HTTPTGS2TP53ALOX12CA2 | |
| SCHEMBL4771303 | 0.77 | HTT (1.00) | HTTPTGS2TP53ALOX12CA2 | |
| SCHEMBL16697767 | 0.76 | HTT (0.73) | HTTPTGS2TP53ALOX12CA2 | |
| SCHEMBL17260096 | 0.76 | PTGS2 (0.77) | HTTPTGS2TP53ALOX12CA2 | |
| SCHEMBL23130840 | 0.75 | HTT (0.72) | HTTPTGS2TP53ALOX12 | |
| SCHEMBL8001635 | 0.75 | MAPT (0.58) | HTTTP53KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |