Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 13/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402645 | 0.86 | PARP1 (0.47) | PARP1HTR2CHTR2AHRH3 | |
| SCHEMBL3403662 | 0.83 | ACACB (0.44) | HTR2CHTR2ALMNA | |
| SCHEMBL3402312 | 0.83 | HTR2C (0.43) | HTR2CHTR2AHRH3LMNA | |
| SCHEMBL3402101 | 0.82 | HTR2C (0.53) | PARP1HTR2CHRH3LMNA | |
| SCHEMBL3405656 | 0.81 | HTR2C (0.45) | PARP1HTR2CHRH3LMNA | |
| SCHEMBL3402974 | 0.79 | KDM4E (0.48) | HTR2CLMNA | |
| SCHEMBL3399942 | 0.78 | HTR2C (0.42) | HTR2CHRH3LMNA | |
| SCHEMBL3402302 | 0.76 | CDC25B (0.46) | LMNA | |
| SCHEMBL13310444 | 0.76 | HTR2C (0.37) | PARP1HTR2CHRH3LMNA | |
| SCHEMBL3402464 | 0.74 | HTR2C (0.52) | PARP1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |