Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 11/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310444 | 0.87 | HTR2C (0.37) | PARP1HTR2CHRH3KDM4E | |
| SCHEMBL3396958 | 0.86 | PARP1 (0.45) | PARP1HRH3PDCD1CD274 | |
| SCHEMBL3400970 | 0.86 | PARP1 (0.42) | PARP1HTR2CHTR2AHRH3 | |
| SCHEMBL3403025 | 0.82 | USP2 (0.49) | HTR2CHTR2AKDM4E | |
| SCHEMBL3399637 | 0.82 | HTR2C (0.48) | HTR2CHTR2AHRH3KDM4E | |
| SCHEMBL3405425 | 0.76 | PARP1 (0.42) | PARP1HTR2CHRH3KDM4EPDCD1 | |
| SCHEMBL3405519 | 0.76 | KDM4E (0.41) | HTR2CKDM4E | |
| SCHEMBL3402464 | 0.75 | HTR2C (0.52) | PARP1HTR2CPDCD1CD274 | |
| SCHEMBL3402101 | 0.74 | HTR2C (0.53) | PARP1HTR2CHRH3KDM4EPDCD1 | |
| SCHEMBL3399942 | 0.74 | HTR2C (0.42) | HTR2CHRH3CCND1CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |