SCHEMBL3401044

SCHEMBL3401044

CCCC(O)(Cc1ccccc1)c1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.70
CYP2C9 P11712 2/20 0.70
CYP2C19 P33261 2/20 0.70
KCNA5 P22460 1/20 0.42
SLC6A2 P23975 2/20 0.41
TAAR1 Q96RJ0 1/20 0.41
FDPS P14324 1/20 0.40
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
CYP3A4 P08684 2/20 0.39
HIF1A Q16665 1/20 0.39
LMNA P02545 1/20 0.38
CYP2D6 P10635 1/20 0.38
ALDH1A1 P00352 1/20 0.38
RECQL P46063 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
TP53 P04637 1/20 0.38
TRPA1 O75762 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9194705 0.86 CYP2C19 (0.52) CYP1A2CYP2C9CYP2C19ESR1ESR2
SCHEMBL9394918 0.84 CYP2C9 (0.50) CYP1A2CYP2C9CYP2C19ESR1ESR2
SCHEMBL7266181 0.84 CYP1A2 (0.76) CYP1A2CYP2C9CYP2C19KCNA5SLC6A2
SCHEMBL28624141 0.83 CYP2C9 (1.00) CYP1A2CYP2C9CYP2C19KCNA5SLC6A2
SCHEMBL23014014 0.82 CYP2C19 (0.48) CYP1A2CYP2C9CYP2C19ESR1ESR2
SCHEMBL28309319 0.80 CYP1A2 (0.63) CYP1A2CYP2C9CYP2C19TAAR1LMNA
SCHEMBL11331380 0.80 CYP2C19 (0.47) CYP1A2CYP2C9CYP2C19ESR1ESR2
SCHEMBL14038639 0.78 CYP2C19 (0.45) CYP1A2CYP2C9CYP2C19LMNAALDH1A1
SCHEMBL2065092 0.78 TAAR1 (0.47) CYP1A2CYP2C9CYP2C19TAAR1LMNA
SCHEMBL2065923 0.78 TAAR1 (0.47) CYP1A2CYP2C9CYP2C19TAAR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2250156-A1 PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES Merck Patent GmbH (DE) 2010-11-17 EP disclosed
WO-2009109259-A1 PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES MERCK PATENT GMBH (DE) 2009-09-11 WO disclosed