Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405498 | 0.91 | HTR2C (0.55) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3399658 | 0.88 | HTR2C (0.58) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL13071981 | 0.87 | MAPT (0.52) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3405318 | 0.87 | HTR2C (0.47) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3405420 | 0.86 | HTR2C (0.78) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3402422 | 0.85 | HTR2C (0.55) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3401487 | 0.85 | HTR2C (0.55) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3398602 | 0.84 | HTR2C (0.57) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3402273 | 0.84 | HTR2C (0.54) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3403609 | 0.83 | HTR2C (0.62) | HTR2CALDH1A1NPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |