Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405420 | 0.89 | HTR2C (0.78) | HTR2CTRPM8NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3404364 | 0.89 | HTR2C (0.51) | HTR2CNPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3399658 | 0.84 | HTR2C (0.58) | HTR2CTRPM8NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3401263 | 0.83 | HTR2C (0.57) | HTR2CTRPM8NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3402386 | 0.83 | HTR2C (0.49) | HTR2CTRPM8NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3398602 | 0.83 | HTR2C (0.57) | HTR2CTRPM8NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13072009 | 0.82 | HTR2C (0.52) | HTR2CTRPM8NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3400942 | 0.82 | HTR2C (0.49) | HTR2CTRPM8NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3402422 | 0.82 | HTR2C (0.55) | HTR2CTRPM8NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3402104 | 0.82 | HTR2C (0.53) | HTR2CNPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |