Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 14/20 | 0.60 |
| ▸ | F10 | P00742 | 13/20 | 0.60 |
| ▸ | F9 | P00740 | 2/20 | 0.52 |
| ▸ | PLG | P00747 | 2/20 | 0.52 |
| ▸ | PLAT | P00750 | 2/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12095849 | 0.92 | F2 (0.60) | F2F10F9PLGPLAT | |
| Trifluoroacetic Acid SCHEMBL3408589 | 0.89 | F2 (0.48) | F2F10F9PLGPLAT | |
| SCHEMBL12095910 | 0.86 | F2 (0.51) | F2F10F9PLGPLAT | |
| Trifluoroacetic Acid SCHEMBL3403811 | 0.85 | F2 (0.61) | F2F10F9PLGPLAT | |
| SCHEMBL3401711 | 0.85 | F2 (0.51) | F2F10F9PLGPLAT | |
| SCHEMBL3407585 | 0.84 | F2 (0.61) | F2F10F9PLGPLAT | |
| SCHEMBL12096009 | 0.84 | F2 (0.54) | F2F10F9PLGPLAT | |
| Hydrochloric Acid SCHEMBL3401696 | 0.84 | F2 (0.62) | F2F10F9PLGPLAT | |
| SCHEMBL3404400 | 0.84 | F2 (0.51) | F2F10F9PLGPLAT | |
| SCHEMBL12095845 | 0.83 | F2 (0.51) | F2F10F9PLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378092-B2 | Chlorothiophene-amides as inhibitors of coagulation factors Xa and thrombin | SANOFI (FR) | 2013-02-19 | — | — | US | disclosed |
| EP-2254881-B1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI SA (FR) | 2012-09-12 | — | — | EP | disclosed |
| EP-2254881-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009103440-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI-AVENTIS (FR) | 2009-08-27 | — | — | WO | disclosed |