SCHEMBL3401510

SCHEMBL3401510

Cc1ccc(-c2cccc(CO)c2)cc1C

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.55
PTGER4 P35408 4/20 0.50
ACMSD Q8TDX5 1/20 0.50
S1PR1 P21453 1/20 0.50
CDK8 P49336 1/20 0.45
CHEK1 O14757 1/20 0.45
MAP2K4 P45985 1/20 0.44
DHODH Q02127 1/20 0.43
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
CHRNA7 P36544 1/20 0.42
FGFR1 P11362 1/20 0.42
HSD17B1 P14061 1/20 0.42
HSD17B2 P37059 1/20 0.42
ADAMTS4 O75173 1/20 0.42
HTR7 P34969 1/20 0.41
ENPP2 Q13822 1/20 0.41
BCL2 P10415 1/20 0.41
FYN P06241 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3401506 0.84 PRKCI (0.50) PRKCIPTGER4ACMSDS1PR1CDK8
SCHEMBL4191589 0.83 PRKCI (0.72) PRKCIACMSDCDK8MAP2K4CHRNB4
SCHEMBL19116911 0.83 PRKCI (0.53) PRKCIPTGER4ACMSDCDK8CHEK1
SCHEMBL1520795 0.82 PRKCI (0.61) PRKCIPTGER4ACMSDCDK8CHEK1
SCHEMBL18297788 0.81 PRKCI (0.76) PRKCIACMSDCDK8MAP2K4CHRNB4
SCHEMBL14960038 0.80 PRKCI (0.58) PRKCIPTGER4ACMSDCDK8MAP2K4
SCHEMBL16578698 0.79 PRKCI (0.68) PRKCIACMSDCDK8CHRNB4CHRNA3
SCHEMBL23750141 0.79 PRKCI (0.67) PRKCIACMSDCDK8MAP2K4DHODH
SCHEMBL5396176 0.79 HTR7 (0.52) HSD17B1HSD17B2HTR7
SCHEMBL3404714 0.79 PRKCI (0.45) PRKCIPTGER4ACMSDS1PR1CDK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2016065-B1 1-(BENZO[D][1,3]DIOXOL-5-YL)-N-(PHENYL)CYCLOPROPANE-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS FOR THE TREATMENT OF CYSTIC FIBROSIS VERTEX PHARMA (US) 2012-09-19 EP disclosed
EP-2259681-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-12-15 EP disclosed
EP-2249646-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2249647-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2249830-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2247184-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-10 EP disclosed
WO-2009100168-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100167-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100170-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100169-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100166-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed