Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.51 |
| ▸ | PPARG | P37231 | 7/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372523 | 1.00 | PPARA (0.51) | PPARAPPARGL3MBTL1TRPM8KLKB1 | |
| SCHEMBL3372464 | 0.91 | PPARA (0.47) | PPARAPPARGL3MBTL1MAPTTP53 | |
| SCHEMBL3373870 | 0.91 | PPARA (0.48) | PPARAPPARGMAPTTP53PPARD | |
| SCHEMBL3369875 | 0.91 | PPARA (0.48) | PPARAPPARGMAPTTP53PPARD | |
| SCHEMBL3369621 | 0.89 | EIF4E (0.41) | PPARAPPARGTP53PPARDTHRB | |
| SCHEMBL6527178 | 0.89 | EIF4E (0.41) | PPARAPPARGTP53PPARDTHRB | |
| SCHEMBL3373193 | 0.86 | PPARG (0.49) | PPARAPPARGL3MBTL1PPARDALDH1A1 | |
| SCHEMBL3368818 | 0.86 | PPARA (0.42) | PPARAPPARGL3MBTL1POLBPPARD | |
| SCHEMBL3375399 | 0.85 | ALDH1A1 (0.47) | PPARAPPARGL3MBTL1MAPTTP53 | |
| SCHEMBL3370434 | 0.84 | PPARA (0.46) | PPARAPPARGTP53PPARDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537091-B1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |