SCHEMBL3401636

SCHEMBL3401636

NCC(c1ccncc1)c1cccc(F)c1

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.48
TAAR1 Q96RJ0 1/20 0.48
AKT1 P31749 1/20 0.48
CYP19A1 P11511 1/20 0.44
SLC6A2 P23975 3/20 0.43
SLC6A4 P31645 3/20 0.43
SLC6A3 Q01959 2/20 0.43
ROCK2 O75116 1/20 0.43
IDO1 P14902 1/20 0.42
TDO2 P48775 1/20 0.42
CHRNB2 P17787 1/20 0.42
CHRNA4 P43681 1/20 0.42
CYP17A1 P05093 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
PDE4A P27815 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3903476 0.88 HTR2A (0.64) HTR2ATAAR1CYP19A1SLC6A2SLC6A4
SCHEMBL6000664 0.88 TAAR1 (0.56) HTR2ATAAR1CYP19A1SLC6A2SLC6A4
SCHEMBL14415600 0.87 HRH1 (0.52) HTR2ATAAR1CYP19A1SLC6A2SLC6A4
SCHEMBL14837325 0.83 ROCK1 (0.45) CYP19A1SLC6A2SLC6A4SLC6A3ROCK2
Ammonia Solution, Strong SCHEMBL6000241 0.82 CYP17A1 (0.51) CYP19A1SLC6A2SLC6A4SLC6A3IDO1
SCHEMBL3400559 0.82 HTR2A (0.73) HTR2ATAAR1AKT1SLC6A2SLC6A4
SCHEMBL3398977 0.80 HTR2A (0.48) HTR2ATAAR1AKT1CYP19A1SLC6A2
SCHEMBL1661916 0.80 HTR2A (0.59) HTR2ATAAR1AKT1CYP19A1SLC6A2
SCHEMBL3914167 0.75 PNMT (0.59) HTR2ATAAR1SLC6A2SLC6A4IDO1
SCHEMBL8070494 0.74 HTR2A (0.42) HTR2ATAAR1CYP19A1SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2249834-A1 SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF ALLERGAN, INC. (US) 2010-11-17 EP disclosed
EP-2240468-A1 SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF ALLERGAN, INC. (US) 2010-10-20 EP disclosed
WO-2009091874-A1 SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF ALLERGAN, INC. (US) 2009-07-23 WO disclosed
WO-2009091759-A1 SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF ALLERGAN, INC. (US) 2009-07-23 WO disclosed