Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10257034 | 0.86 | — | — | |
| SCHEMBL19905736 | 0.85 | SMYD3 (0.41) | SMYD3MMETSHRKMT2ASMN1; SMN2 | |
| SCHEMBL13625350 | 0.81 | SMYD3 (0.60) | SMYD3KMT2A | |
| SCHEMBL3401705 | 0.81 | SMYD3 (0.60) | SMYD3KMT2A | |
| SCHEMBL8006185 | 0.79 | EPHX1 (0.52) | SMYD3KMT2ASMN1; SMN2KDM4EATM | |
| SCHEMBL3502524 | 0.78 | SMYD3 (0.41) | SMYD3TSHRBTKKMT2ASMN1; SMN2 | |
| SCHEMBL3502523 | 0.78 | SMYD3 (0.41) | SMYD3TSHRBTKKMT2ASMN1; SMN2 | |
| SCHEMBL3502526 | 0.78 | SMYD3 (0.41) | SMYD3TSHRBTKKMT2ASMN1; SMN2 | |
| SCHEMBL27795399 | 0.78 | SMYD3 (0.41) | SMYD3TSHRBTKKMT2ASMN1; SMN2 | |
| SCHEMBL15247302 | 0.77 | SMYD3 (0.40) | SMYD3BTKKMT2AKDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |