Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.71 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.71 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | GPR183 | P32249 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857107 | 0.89 | KMT2A (0.68) | CYP2D6CYP2C19DUSP3PTPN5PTPN11 | |
| SCHEMBL21122195 | 0.86 | KMT2A (0.64) | CYP2D6CYP2C19DUSP3PTPN5PTPN11 | |
| SCHEMBL16299414 | 0.84 | ALDH1A1 (0.65) | CYP2D6CYP2C19DUSP3PTPN5PTPN11 | |
| SCHEMBL3233139 | 0.84 | ALDH1A1 (0.65) | CYP2D6CYP2C19DUSP3PTPN5PTPN11 | |
| SCHEMBL2377318 | 0.84 | ALDH1A1 (0.69) | CYP2D6CYP2C19DUSP3PTPN5PTPN11 | |
| SCHEMBL10211716 | 0.84 | ALDH1A1 (0.69) | KMT2APOLBALDH1A1HPGDNAMPT | |
| SCHEMBL1192814 | 0.83 | KMT2A (0.71) | KMT2APOLBALDH1A1HPGDNAMPT | |
| SCHEMBL19623533 | 0.81 | ALDH1A1 (0.62) | CYP2D6CYP2C19DUSP3PTPN5PTPN11 | |
| SCHEMBL1950937 | 0.81 | ALDH1A1 (0.62) | CYP2D6CYP2C19DUSP3PTPN5PTPN11 | |
| SCHEMBL19634400 | 0.81 | ALDH1A1 (0.62) | CYP2D6CYP2C19DUSP3PTPN5PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420657-B2 | Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2013-04-16 | — | — | US | disclosed |
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | CYP2D6 240/4885CYP2C19 328/4885DUSP3 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.