Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | SELL | P14151 | 2/20 | 0.38 |
| ▸ | SELP | P16109 | 2/20 | 0.38 |
| ▸ | SELE | P16581 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093857 | 0.85 | — | — | |
| SCHEMBL3402820 | 0.84 | SMN1; SMN2 (0.46) | TSHRKDM4EKMT2ASMN1; SMN2MME | |
| SCHEMBL12436696 | 0.80 | KMT2A (0.40) | KMT2ASMN1; SMN2SELLSELPSELE | |
| SCHEMBL12513739 | 0.80 | KMT2A (0.40) | KMT2ASMN1; SMN2SELLSELPSELE | |
| SCHEMBL30388545 | 0.79 | KDM4E (0.40) | KDM4EKMT2ASMN1; SMN2MMELMNA | |
| SCHEMBL473560 | 0.79 | SMYD3 (0.50) | KMT2ASMN1; SMN2LMNAHPGDEPHX1 | |
| SCHEMBL473561 | 0.79 | SMYD3 (0.50) | KMT2ASMN1; SMN2LMNAHPGDEPHX1 | |
| SCHEMBL19502831 | 0.78 | TSHR (0.41) | TSHRKDM4EKMT2ASMN1; SMN2MME | |
| SCHEMBL3401676 | 0.78 | NPSR1 (0.64) | TSHRKDM4EKMT2ASMN1; SMN2MME | |
| Hydrochloric Acid SCHEMBL13275803 | 0.78 | SMYD3 (0.49) | KMT2ASMN1; SMN2LMNAHPGDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |