Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.53 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11983434 | 0.81 | PSMB5 (0.58) | PSMB5PSMB1HTR2AHTR1ADRD2 | |
| SCHEMBL2697790 | 0.80 | PSMB5 (0.56) | PSMB5PSMB1HTR2AHTR1ADRD2 | |
| SCHEMBL2695944 | 0.79 | PSMB5 (0.53) | PSMB5PSMB1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL18885926 | 0.78 | PSMB5 (0.57) | PSMB5PSMB1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL1623538 | 0.77 | ACVR1 (0.50) | PSMB5PSMB1HTR2AHTR1ADRD2 | |
| SCHEMBL30529323 | 0.77 | ACVR1 (0.50) | PSMB5PSMB1HTR2AHTR1ADRD2 | |
| SCHEMBL29891007 | 0.76 | PSMB5 (0.47) | PSMB5PSMB1HTR2AHTR1ADRD2 | |
| SCHEMBL31123005 | 0.76 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2LMNARAB9AHTT | |
| SCHEMBL179074 | 0.76 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2LMNARAB9AHTT | |
| SCHEMBL12640059 | 0.75 | RPS6KA5 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |