Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15845891 | 0.82 | KMT2A (0.52) | KMT2APOLBLMNARAB9AMEN1 | |
| SCHEMBL31572148 | 0.82 | KMT2A (0.52) | KMT2APOLBLMNARAB9AMEN1 | |
| SCHEMBL10329164 | 0.81 | RPS6KA5 (0.41) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL24968315 | 0.79 | TRPA1 (0.40) | NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL27233836 | 0.77 | NPC1 (0.42) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL30851323 | 0.77 | NPC1 (0.42) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL26615066 | 0.77 | PSMB5 (0.52) | PSMB5PSMB1NPC1KMT2AEGFR | |
| SCHEMBL3402123 | 0.76 | PSMB5 (0.53) | PSMB5PSMB1HTR2AHTR1ADRD2 | |
| SCHEMBL2315637 | 0.75 | DGAT1 (0.38) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL30603038 | 0.75 | PSMB5 (0.50) | PSMB5PSMB1NPC1KMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291235-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |