Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 12/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 12/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 12/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 12/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400563 | 1.00 | POLB (0.34) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL14136838 | 1.00 | POLB (0.34) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4702729 | 0.96 | CHRM2 (0.33) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3403167 | 0.90 | POLB (0.35) | POLB | |
| SCHEMBL2687375 | 0.90 | POLB (0.35) | POLB | |
| SCHEMBL2346750 | 0.90 | POLB (0.35) | POLB | |
| SCHEMBL3399866 | 0.82 | KMT2A (0.38) | — | |
| SCHEMBL3402893 | 0.82 | KMT2A (0.38) | — | |
| SCHEMBL3402447 | 0.82 | KMT2A (0.38) | — | |
| SCHEMBL3400583 | 0.81 | DPP4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| US-8394789-B2 | (Dihydro)pyrrolo[2,1-α]isoquinolines | MSD OSS B.V. (NL) | 2013-03-12 | — | — | US | disclosed |
| EP-2252611-A1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. Organon (NL) | 2010-11-24 | — | — | EP | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009098283-A1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2009-08-13 | — | — | WO | disclosed |