Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 9/20 | 0.34 |
| ▸ | PREP | P48147 | 5/20 | 0.34 |
| ▸ | FAP | Q12884 | 6/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399854 | 1.00 | DPP4 (0.34) | DPP4DPP7PREPFAPDPP8 | |
| SCHEMBL14311832 | 0.90 | PIN1 (0.31) | PIN1 | |
| SCHEMBL3424333 | 0.90 | PIN1 (0.31) | PIN1 | |
| SCHEMBL3397410 | 0.90 | PIN1 (0.31) | PIN1 | |
| SCHEMBL3400563 | 0.81 | POLB (0.34) | — | |
| SCHEMBL3402133 | 0.81 | POLB (0.34) | — | |
| SCHEMBL14136838 | 0.81 | POLB (0.34) | — | |
| SCHEMBL3399177 | 0.80 | PIN1 (0.37) | PIN1 | |
| SCHEMBL4702729 | 0.78 | CHRM2 (0.33) | — | |
| SCHEMBL3402447 | 0.75 | KMT2A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |