Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16799726 | 0.91 | MAPT (0.59) | MAPTPOLBHPGDCYP3A4KMT2A | |
| SCHEMBL3402321 | 0.86 | MAPT (0.52) | MAPTPOLBHPGDCYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL984179 | 0.85 | MAPT (0.51) | MAPTPOLBHPGDCYP3A4KMT2A | |
| SCHEMBL13201338 | 0.84 | POLB (0.65) | MAPTPOLBHPGDCYP3A4KMT2A | |
| SCHEMBL31524234 | 0.84 | KMT2A (0.56) | MAPTPOLBHPGDCYP3A4KMT2A | |
| SCHEMBL24116980 | 0.82 | KMT2A (0.58) | MAPTPOLBHPGDCYP3A4KMT2A | |
| SCHEMBL30832082 | 0.82 | KMT2A (0.58) | MAPTPOLBHPGDCYP3A4KMT2A | |
| SCHEMBL1674736 | 0.82 | KMT2A (0.58) | MAPTPOLBHPGDCYP3A4KMT2A | |
| SCHEMBL13890273 | 0.81 | MAPT (0.58) | MAPTHPGDCYP3A4KMT2AMEN1 | |
| SCHEMBL3915204 | 0.79 | MAPT (0.52) | MAPTPOLBHPGDCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |