Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405280 | 0.89 | HTR2C (0.53) | HTR2CCNR1PARP1MAPTMEN1 | |
| SCHEMBL3402656 | 0.88 | HTR2C (0.48) | HTR2CCNR1PARP1MAPTSMN1; SMN2 | |
| SCHEMBL3401691 | 0.88 | HTR2C (0.45) | HTR2CCNR1MAPTSMN1; SMN2HTT | |
| SCHEMBL3402439 | 0.88 | HTR2C (0.46) | HTR2CCNR1PARP1NPC1RAB9A | |
| SCHEMBL13309912 | 0.87 | HTR2C (0.59) | HTR2CCNR1PARP1MAPTSMN1; SMN2 | |
| SCHEMBL3397009 | 0.86 | HTR2C (0.45) | HTR2CCNR1PARP1MAPTALDH1A1 | |
| SCHEMBL3399364 | 0.86 | HTR2C (0.45) | HTR2CCNR1MAPTMEN1KMT2A | |
| SCHEMBL3400042 | 0.86 | HTR2C (0.58) | HTR2CCNR1PARP1MAPTSMN1; SMN2 | |
| SCHEMBL3401442 | 0.85 | HTR2C (0.46) | HTR2CCNR1PARP1ALDH1A1HPGD | |
| SCHEMBL3404790 | 0.85 | HTR2C (0.57) | HTR2CCNR1PARP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |