Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14546080 | 0.92 | HTR2C (0.45) | HTR2CCNR1HRH3CFTRCYP2C19 | |
| SCHEMBL3402439 | 0.86 | HTR2C (0.46) | HTR2CCNR1HRH3CFTRSLC6A2 | |
| SCHEMBL3402453 | 0.85 | HTR2C (0.55) | HTR2CCNR1HRH3CES2ALDH1A1 | |
| SCHEMBL3397009 | 0.84 | HTR2C (0.45) | HTR2CCNR1HRH3CFTRSLC6A2 | |
| SCHEMBL3401691 | 0.84 | HTR2C (0.45) | HTR2CCNR1HRH3CFTRSLC6A2 | |
| SCHEMBL3399364 | 0.84 | HTR2C (0.45) | HTR2CCNR1HRH3CFTRHDAC1 | |
| SCHEMBL3402221 | 0.83 | CNR1 (0.46) | HTR2CCNR1HRH3CFTRALDH1A1 | |
| SCHEMBL3400850 | 0.83 | HTR2C (0.45) | HTR2CHRH3ALDH1A1HPGD | |
| SCHEMBL3404564 | 0.82 | CFTR (0.52) | HTR2CCNR1CFTRHDAC6ALDH1A1 | |
| SCHEMBL3404031 | 0.82 | HTR2C (0.47) | HTR2CCNR1HRH3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |