Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404973 | 0.94 | HTR2C (0.46) | HTR2CALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL3402597 | 0.92 | HTR2C (0.46) | HTR2CALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL3405840 | 0.91 | HTR2C (0.50) | HTR2CALDH1A1LMNATHRATHRB | |
| SCHEMBL3401249 | 0.91 | HTR2C (0.50) | HTR2CALDH1A1LMNATHRATHRB | |
| SCHEMBL3405842 | 0.90 | HTR2C (0.53) | HTR2CALDH1A1CNR1THRATHRB | |
| SCHEMBL3400300 | 0.89 | HTR2C (0.56) | HTR2CALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL3405439 | 0.88 | HTR2C (0.46) | HTR2CALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL3402305 | 0.88 | HTR2C (0.48) | HTR2CALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL3400495 | 0.86 | HTR2C (0.46) | HTR2CALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL3405642 | 0.85 | HTR2C (0.50) | HTR2CALDH1A1LMNATHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |