Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.42 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405840 | 1.00 | HTR2C (0.50) | HTR2CMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3405842 | 0.95 | HTR2C (0.53) | HTR2CMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3405642 | 0.94 | HTR2C (0.50) | HTR2CMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3402415 | 0.94 | HTR2C (0.50) | HTR2CMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3400491 | 0.92 | L3MBTL1 (0.50) | HTR2CMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3403297 | 0.92 | L3MBTL1 (0.50) | HTR2CMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3402611 | 0.91 | HTR2C (0.46) | HTR2CALDH1A1LMNATHRATHRB | |
| SCHEMBL3402711 | 0.90 | ACKR3 (0.49) | HTR2CMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3403453 | 0.90 | ACKR3 (0.49) | HTR2CMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3404356 | 0.89 | HTR2C (0.61) | HTR2CMEN1KMT2AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |