Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071989 | 0.93 | CHRM4 (0.47) | CHRM4ACKR3TLR9TLR8TLR7 | |
| SCHEMBL3399791 | 0.88 | CHRM4 (0.49) | CHRM4ACKR3TLR9TLR8TLR7 | |
| SCHEMBL3402641 | 0.88 | CHRM4 (0.49) | CHRM4ACKR3TLR9TLR8TLR7 | |
| SCHEMBL3402603 | 0.85 | TLR9 (0.53) | CHRM4ACKR3TLR9TLR8TLR7 | |
| SCHEMBL3399763 | 0.85 | CHRM4 (0.51) | CHRM4ACKR3TLR9TLR8TLR7 | |
| SCHEMBL3400749 | 0.84 | CHRM4 (0.49) | CHRM4ACKR3TLR9TLR8TLR7 | |
| SCHEMBL3405389 | 0.83 | CHRM4 (0.48) | CHRM4ACKR3TLR9TLR8TLR7 | |
| SCHEMBL3403904 | 0.83 | CHRM4 (0.47) | CHRM4ACKR3TLR9TLR8TLR7 | |
| SCHEMBL3401785 | 0.83 | ACKR3 (0.54) | CHRM4ACKR3PPARDPPARACHRM3 | |
| SCHEMBL3399769 | 0.82 | DRD2 (0.48) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |