Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Marimastat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 known ✓ | P03956 | 9/20 | 1.00 |
| ▸ | MMP2 known ✓ | P08253 | 8/20 | 1.00 |
| ▸ | MMP3 known ✓ | P08254 | 6/20 | 1.00 |
| ▸ | MMP9 known ✓ | P14780 | 5/20 | 1.00 |
| ▸ | MMP7 known ✓ | P09237 | 3/20 | 1.00 |
| ▸ | MMP12 known ✓ | P39900 | 1/20 | 1.00 |
| ▸ | ADAM17 | P78536 | 13/20 | 1.00 |
| ▸ | MMP8 | P22894 | 6/20 | 1.00 |
| ▸ | MMP13 | P45452 | 3/20 | 1.00 |
| ▸ | TNF | P01375 | 2/20 | 1.00 |
| ▸ | MMP20 | O60882 | 1/20 | 1.00 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 1.00 |
| ▸ | MMP10 | P09238 | 1/20 | 1.00 |
| ▸ | MMP14 | P50281 | 1/20 | 1.00 |
| ▸ | MMP15 | P51511 | 1/20 | 1.00 |
| ▸ | MMP16 | P51512 | 1/20 | 1.00 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 1.00 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 1.00 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 1.00 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Marimastat SCHEMBL31231856 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL134999 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL1821430 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL13575773 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL8189167 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL13253251 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL8193003 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL17799241 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL20793036 | 1.00 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3MMP8 | |
| Marimastat SCHEMBL7931107 | 0.99 | ADAM17 (0.97) | ADAM17MMP1MMP2MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 30781 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744663-A2 | SKIN COMPOSITION | Eaderm Co., Ltd. (JP) | 2026-05-20 | — | — | EP | claimed |
| US-20260125650-A1 | METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES | TRAILHEAD BIOSYSTEMS INC (US) | 2026-05-07 | — | — | US | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| US-20260116847-A1 | Crystalline polymorphic forms of marimastat, an amorphous form of marimastat, processes for their preparation, pharmaceutical compositions comprising the same, and uses thereof | PIKRALIDA SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (PL) | 2026-04-30 | — | — | US | claimed |
| US-12577255-B2 | MDM2-based modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2026-03-17 | — | — | US | claimed |
| EP-4704832-A2 | BIFUNCTIONAL SMALL MOLECULES TO TARGET THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS | Biohaven Therapeutics Ltd. (VG) | 2026-03-11 | — | — | EP | claimed |
| US-12564575-B2 | Early management, mitigation and prevention of sepsis and sepsis-like syndromes, including neo-natal ARDS due to infection, injury or iatrogenesis | OPHIREX, INC (US) | 2026-03-03 | — | — | US | claimed |
| US-12548678-B2 | Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus | AMPEL BIOSOLUTIONS, LLC (US) | 2026-02-10 | — | — | US | claimed |
| US-20260022117-A1 | COMPOUNDS AND METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS | ARVINAS OPERATIONS INC (US) | 2026-01-22 | — | — | US | claimed |
| US-12522572-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-01-13 | — | — | US | claimed |
| US-5948780-A | ADMINISTERING A METALLOPROTEINASE INHIBITOR | WARNER-LAMBERT COMPANY (US) | 1999-09-07 | — | — | US | claimed |
| EP-0883398-A4 | METHOD OF INHIBITING PHOTOAGING OF SKIN | UNIV MICHIGAN (US) | 1999-05-12 | — | — | EP | claimed |
| CN-1211178-A | Method for inhibiting skin photoaging | UNIV MICHIGAN (US) | 1999-03-17 | — | — | CN | claimed |
| EP-0883398-A1 | METHOD OF INHIBITING PHOTOAGING OF SKIN | THE UNIVERSITY OF MICHIGAN (US) | 1998-12-16 | — | — | EP | claimed |
| US-5837224-A | Method of inhibiting photoaging of skin | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1998-11-17 | — | — | US | claimed |
| WO-1998047532-A1 | EMBOLUS THERAPY USING INSOLUBLE MICROPARTICLES OR VESICLES CONTAINING CONTRAST AGENTS | NYCOMED IMAGING AS (NO) | 1998-10-29 | — | — | WO | claimed |
| WO-1998040088-A1 | COMPOSITIONS FOR TREATING TUMORS CONTAINING SHARK CARTILAGE EXTRACTS AND ANTI-NEOPLASTIC AGENTS | LES LABORATOIRES AETERNA INC. (CA) | 1998-09-17 | — | — | WO | claimed |
| WO-1998025597-A2 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 1998-06-18 | — | — | WO | claimed |
| WO-1998024474-A1 | INHIBITION OF INVASIVE REMODELLING | FONDEN TIL FREMME AF EKSPERIMENTEL CANCERFORSKNING (DK) | 1998-06-11 | — | — | WO | claimed |
| WO-1997025969-A1 | METHOD OF INHIBITING PHOTOAGING OF SKIN | THE UNIVERSITY OF MICHIGAN (US) | 1997-07-24 | — | — | WO | claimed |