Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405539 | 0.91 | HRH3 (0.49) | ALDH1A1POLBCDC7DBF4CNR1 | |
| SCHEMBL3406012 | 0.91 | HRH3 (0.49) | ALDH1A1POLBCDC7DBF4CNR1 | |
| SCHEMBL3403938 | 0.89 | CNR1 (0.51) | ALDH1A1CNR1HRH3HPGDSMN1; SMN2 | |
| SCHEMBL3401239 | 0.89 | PIK3CA (0.49) | ALDH1A1POLBCDC7DBF4CNR1 | |
| SCHEMBL3401857 | 0.87 | CNR1 (0.51) | ALDH1A1POLBCNR1HRH3HPGD | |
| SCHEMBL3403718 | 0.86 | CNR1 (0.54) | ALDH1A1CNR1HRH3HPGDSMN1; SMN2 | |
| SCHEMBL3405048 | 0.85 | CNR1 (0.49) | ALDH1A1CNR1HRH3HPGDSMN1; SMN2 | |
| SCHEMBL3405508 | 0.85 | HRH3 (0.55) | ALDH1A1CNR1HRH3HPGDSMN1; SMN2 | |
| SCHEMBL3404388 | 0.84 | HRH3 (0.54) | ALDH1A1CNR1HRH3HPGDSMN1; SMN2 | |
| SCHEMBL3398825 | 0.84 | SCN5A (0.54) | ALDH1A1POLBCNR1HRH3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |