Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405508 | 0.99 | HRH3 (0.55) | HRH3ALDH1A1SMN1; SMN2GAATSHR | |
| SCHEMBL3400922 | 0.91 | PKM (0.47) | HRH3ALDH1A1SMN1; SMN2GAATSHR | |
| SCHEMBL3405591 | 0.91 | HRH3 (0.55) | HRH3CNR1ACACBACACATHRA | |
| SCHEMBL13309675 | 0.91 | HRH3 (0.55) | HRH3CNR1ACACBACACATHRA | |
| SCHEMBL13309807 | 0.90 | HRH3 (0.56) | HRH3CNR1ACACBACACATHRA | |
| SCHEMBL3398959 | 0.90 | HRH3 (0.56) | HRH3CNR1ACACBACACATHRA | |
| SCHEMBL3403718 | 0.89 | CNR1 (0.54) | HRH3ALDH1A1SMN1; SMN2GAACNR1 | |
| SCHEMBL3405392 | 0.89 | CNR1 (0.55) | HRH3ALDH1A1SMN1; SMN2CNR1HPGD | |
| SCHEMBL3402224 | 0.88 | HRH3 (0.48) | HRH3ALDH1A1SMN1; SMN2GAATSHR | |
| SCHEMBL3400395 | 0.87 | CNR1 (0.52) | HRH3ALDH1A1SMN1; SMN2KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |