Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SIGLEC9 | Q9Y336 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399675 | 0.89 | HTR2C (0.51) | HTR2CCNR1THRBTHRAOXTR | |
| SCHEMBL13072006 | 0.86 | CNR1 (0.45) | HTR2CCNR1THRBTHRAOXTR | |
| SCHEMBL3405480 | 0.85 | THRB (0.49) | HTR2CCNR1THRBTHRAOXTR | |
| SCHEMBL3400826 | 0.85 | HTR2C (0.48) | HTR2CCNR1THRBTHRAOXTR | |
| SCHEMBL3401068 | 0.85 | HTR2C (0.48) | HTR2CCNR1THRBTHRAOXTR | |
| SCHEMBL3404351 | 0.83 | HTR2C (0.49) | HTR2CCNR1THRBTHRAOXTR | |
| SCHEMBL3405718 | 0.82 | HTR2C (0.58) | HTR2CCNR1THRBTHRAOXTR | |
| SCHEMBL3400092 | 0.81 | HTR2C (0.47) | HTR2CCNR1THRBTHRACES2 | |
| SCHEMBL3405458 | 0.81 | HTR2C (0.47) | HTR2CCNR1THRBTHRACES2 | |
| SCHEMBL3405078 | 0.81 | HTR2C (0.47) | HTR2CCNR1THRBTHRACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |