Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400042 | 0.88 | HTR2C (0.58) | HTR2CCNR1CES2PARP1HRH3 | |
| SCHEMBL13309912 | 0.87 | HTR2C (0.59) | HTR2CCNR1CES2PARP1HRH3 | |
| SCHEMBL3399722 | 0.85 | HTR2C (0.55) | HTR2CCNR1PPARDPPARACES2 | |
| SCHEMBL3402963 | 0.85 | HTR2C (0.57) | HTR2CCNR1CES2PARP1HRH3 | |
| SCHEMBL3404790 | 0.85 | HTR2C (0.57) | HTR2CCNR1PPARDPPARACES2 | |
| SCHEMBL3398799 | 0.84 | HTR2C (0.78) | HTR2CCNR1CES2PARP1 | |
| SCHEMBL3404951 | 0.84 | HTR2C (0.56) | HTR2CCNR1CES2PARP1HRH3 | |
| SCHEMBL3403332 | 0.83 | HTR2C (0.55) | HTR2CCNR1CES2PARP1 | |
| SCHEMBL3402453 | 0.83 | HTR2C (0.55) | HTR2CCNR1CES2PARP1HRH3 | |
| SCHEMBL3400778 | 0.83 | HTR2C (0.57) | HTR2CCNR1CES2PARP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |