Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | TDO2 | P48775 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25045387 | 0.85 | KMT2A (0.56) | MAPK1SMN1; SMN2KMT2ATP53MAPT | |
| SCHEMBL3406655 | 0.83 | POLB (0.62) | ALDH1A1POLBMAPK1SMN1; SMN2RXFP1 | |
| SCHEMBL15741969 | 0.81 | SMN1; SMN2 (0.63) | ALDH1A1POLBMAPK1SMN1; SMN2RXFP1 | |
| SCHEMBL25044743 | 0.79 | SLC5A1 (0.57) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL15897976 | 0.78 | CA12 (0.53) | ALDH1A1MAPK1SMN1; SMN2TP53MAPT | |
| SCHEMBL30282905 | 0.77 | TP53 (0.49) | ALDH1A1MAPK1SMN1; SMN2TP53MAPT | |
| SCHEMBL14710979 | 0.77 | SLC5A1 (0.59) | ALDH1A1MAPK1SMN1; SMN2TP53MAPT | |
| SCHEMBL4495998 | 0.77 | RXFP1 (0.48) | ALDH1A1POLBMAPK1SMN1; SMN2RXFP1 | |
| SCHEMBL20028111 | 0.77 | TP53 (0.66) | ALDH1A1MAPK1SMN1; SMN2KMT2ATP53 | |
| SCHEMBL25044788 | 0.77 | ADORA1 (0.47) | SMN1; SMN2KMT2ATP53MAPTSLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |