Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409150 | 0.87 | EGLN1 (0.56) | EGLN1PTGER4 | |
| SCHEMBL4530398 | 0.80 | EGLN1 (0.50) | EGLN1KAT6APTGER4 | |
| SCHEMBL3410878 | 0.79 | EGLN1 (0.63) | EGLN1LMNA | |
| SCHEMBL3409230 | 0.79 | EGLN1 (0.55) | EGLN1PTGER4KDM4E | |
| SCHEMBL3435037 | 0.78 | EGLN1 (0.45) | EGLN1BCL6NCOR2KDM4ECYP1A2 | |
| SCHEMBL3408985 | 0.77 | MEN1 (0.45) | EGLN1KAT6AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL3411160 | 0.77 | EGLN1 (0.49) | EGLN1HCRTR1 | |
| SCHEMBL3408688 | 0.77 | EGLN1 (0.48) | EGLN1 | |
| SCHEMBL3409508 | 0.75 | EGLN1 (0.64) | EGLN1PTGER4 | |
| SCHEMBL3408585 | 0.75 | EGLN1 (0.64) | EGLN1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | claimed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | claimed |